ANGIOGENESIS, TISSUE HYPOXIA AND OXIDATIVE STRESS DURING MOTOR ACTIVITY OF VARIOUS DIRECTIONS AND INTENSITY

Abstract

The study of the mechanisms of OS- induced effects with typical of it hypoxia-induced gene expression, is important in searching criteria for evaluation and prediction of physical efficiency. Recent studies have shown that oxygen-sensitive protein complex with transcriptional activity, namely hypoxia-induced factor (HIF-1α) plays the key role in the process of maintaining balance between the need for oxygen in living cells and its delivery. In mammals, HIF-1α is considered a leading inducer of transcription gene expression which responds to the lack of oxygen. HIF-1α is activated in physiologically important sites of oxygen pathway regulation, providing quick and adequate response to hypoxic stress, and, in particular, the expression of genes controlling the formation and growth of new blood vessels.