Browsing by Author "Danylchenko, S."

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ASSESSMENT OF MEDICAL ERRORS IN DENTISTRY
(2023) Babkina, O.; Danylchenko, S.; Данильченко, С. І.
The purpose of the work was to analyze the situation with the provision of dental services by medical staff of dental clinics and to analyze medical records to establish/refute the presence of defects in the provision of services. Results. As a result of the analysis of 56 cases of dental services, it was found that surgical dental services (implantation) in most cases are provided in accordance with generally accepted recommendations. In most cases, medical records in dental clinics are properly drawn up, which is of great importance in its study and analysis of the presence/absence of defects during dental manipulations at the time of forensic medical examinations. However, in 10% the medical records of the dental patient were improperly issued, the dates of admission were not specified, the scope of the manipulations performed was not described, the review of the control examination was not scheduled, the necessary instrumental methods of examination were not appointed, the recommendations for cavity care were not provided, etc. Conclusion. The problem of providing services of inadequate quality and improper performance of the professional duties by dental clinics staff, careless and dishonest attitude to their professional duties remains relevant. Medical records data of dental clinics allow experts to analyze the nature, scope, stages and completeness of the provision of dental services, identify/refute the presence of defects in the proper/improper provision of surgical services (implantation) by dental clinics staff, establish/refute a causal relationship between the actions of dental clinics staff and consequences in patients.
CHALLENGES AND OPPORTUNITIES OF THE GLOBAL HEALTH CARE SYSTEM IN THE ERA OF DIGITAL AND GENOME INNOVATIONS
(2024) Golovchenko, І.; Danylchenko, S.; Horoshko, V.; Головченко, І.
The global healthcare system is going through a period of complex change due to global changes in technology and treatment methods. There is an urgent need to ensure the availability and safety of the use of medical innovations, taking into account the social determinants of population health, which require significant financial costs and new political solutions. To develop appropriate strategic approaches and principles of management of the modern health care system, politicians need to take into account the behavioral aspects of citizens and the peculiarities of the nation as a whole, which affect the economic and social factors that shape the living conditions of the population. Financial infusions alone cannot solve the problem. Statistics over the past decade show that health care costs have been rising steadily in almost every country. Now it reaches 5-10% of GDP depending on the level of economic development of the country. The realization that the entire system is failing in all directions, despite the growth of financial investments in health care, is an unprecedented manifestation of the situation in terms of preserving the health of the global population as a whole and requires urgent multidisciplinary intervention by health care workers and political figures. Concerns about the current and future state of public health are growing not only in Ukraine, but also in almost every country. Expectations for the solution of many problems are anchored in the first process of convergence of the digital and genomic revolutions in health care. This is expected to improve citizens' health, reduce healthcare costs and make treatment more personalized. At the same time, the available experience and practice of applying all these innovations shows that there are risks that must be considered along with the results when we talk about the future health of the entire population of the planet.
DIAGNOSTICS OF THE PRESCRIPTION OF DAMAGE TO THE PANCREAS IN EXPLOSIVE TRAUMA AND GUNSHOT WOUNDS DURING A MILITARY CONFLICT
(2022) Babkina, O.; Danylchenko, S.; Данильченко, С. І.
Introduction: Quite often a pancreatic injury is observed in combi- nation with the injury of other organs of the abdominal cavity during explosive trauma and gunshot wounds during a military conflict. Purpose: To study the dynamic changes of histological parameters injured pancreas tissues in various types, depending on the period of injury. Materials and methods: The material for the study included tissues of 52 male and female pancreases, aged from 20 to 54 who died of injury of explosive trauma and gunshot wounds during a military conflict. In the conducted research we used histological and histochemical techniques.
DYNAMICS OF BIOCHEMICAL MARKERS OF THE CONNECTIVE TISSUE METABOLISM IN THE BLOOD OF RATS AFTER INSERTION OF STEEL IMPLANTS WITH DIAMOND-LIKE CARBON COATING INTO THE FEMUR
(2021) Makarov, V.; Morozenko, D.; Gliebova, K.; Danylchenko, S.; Данильченко, С. І.
Objective: It is known that the regeneration of bone tissue after implantation of any structures depends on the coating of their surface. Therefore, the research of the influence of steel implants with diamond-like carbon coating on regeneration of bone tissue in the dynamics after implantation is a topical issue. Material and Methods: The study was conducted on 61 male rats, 5 of them were intact animals. There were also 2 groups of rats with 28 animals in each group (the 1 st group was the control one where implants were without diamond-like carbon coating, the 2 nd group was experimental where the implants were without coating). We determined the content of glycoproteins, chondroitin sulfates, alkaline phosphatase, total calcium, oxyproline and osteocalcin in the blood of rats on the 7th , 14th, 30th and 90th days after implantation. Results and Discussion: Group 2 rats had a faster osteointegration compared with the group 1 rats, which was manifested by the normalization of biochemical markers of bone metabolism (glycoproteins, chondroitinsulfats, oxyproline and osteocalcin) on the 90th day of an experiment. Conclusion: Using steel implants with diamond-like carbon coatings showed that the content of glycoproteins and chondroitin sulfates increased only on the 7th day; oxyproline and osteocalcin increased on the 7th , 14th and 30th days after implantation; on the 90th day the rates of these biochemical markers reached the norm, indicating a high efficiency of osteointegration.
ENERGY PRODUCTING AND APOPTOSIS AT PHYSICAL LOADS: THE ROLE OF THE CHANGES THE PROOXIDANT-ANTIOXIDANT BALANCE (A REVIEW)
(2020) Voitenko, V.; Gunina, L.; Danylchenko, S.; Nosach, O.; Данильченко, С. І.
The article notes that the development of oxidative stress and the violation of cellular energy balance is the primary link of the vast majority of systemically-forming homeostatic shifts in the athlete’s body and changes the vital structure and function of cellular and subcellular proteins membrane. Changes in the quantitative and qualitative composition of lipid components of membranes, inhibition of the activity of key glycolysis enzymes, as well as the deterioration of bioenergy mechanisms, result from the accumulation of free radicals due to activation of lipid peroxidation. The protection of the organelles responsible for energy supply from oxidative effects is provided by mitochondrial disconnecting proteins that exist in the myocardium. The development of metabolic ischemia due to the imbalance between the delivery of oxygen to cardiomyocytes and their need for myocardium is accompanied firstly by the inhibition of the process of oxidation of glucose and an increase in the use of fatty acids, and then the accumulation of lactate with the development of acidosis of the intracellular environment and the impairment of the ability of myocytes and cardiomyocytes to relaxtion and contraction. It has been established that strenuous muscle activity leads to the formation of a hypoxic state with its characteristic redistribution and increase of energy, metabolic, structural resources of the body in the interests of the tissue where adaptive adjustments are taking place. The insufficiency of energy generation due to the development of this state leads to the dysfunction of the mitochondrial apparatus, which subsequently causes the violation of the energy supply, antioxidant protection, membrane stability due to intensification of lipid peroxidation and leads to cell apoptosis. This forms a background for the occurrence of fatigue and tension, followed by reduction of physical performance of athletes. The detection of the above changes makes it possible to prevent and correct in a timely manner the negative effects of oxidative stress associated with ultra-intensive physical loads.
EXPERIENCE OF DETERMINING THE PRIORITY OF COMPLEX PROCESS OR SYSTEM (ON THE EXAMPLE OF PHYSICAL EDUCATION AND SPORT)
(2020) Olkhovyі, O.; Chernozub, A.; Danylchenko, S.; Korchagin, М.; Romanchuk, S.; Oderov, A.; Klymovych, V.; Zhembrovskyi, S.; Данильченко, С. І.
The most used in today's methods of expert assessments (questionnaires, surveys, brainstorming) have a number of underestimations, the main of which is that the consistency and logic of expert statements are not determined. To solve this problem field, a computer program has been created for collecting, saving, quantitative comparison and operational processing of the results obtained through a collective expert evaluation. The article describes the mathematical algorithm of this program. As a base of the program, due to the combination of elements of the Delphi expert survey and the method of modern theory of hierarchical systems T. Saati, the procedure of synthesis of priorities is taken, which is calculated on the basis of subjective expert estimation. The priority or weighting factor is determined on the basis of the individual judgment pair comparison principle of the expert on the priority (the degree of advantage, weight) of one component of a particular process over another. In this work, the method of simple iteration is used. The created program establishes the judgments coherence and logic degree of each of the experts. That is, by way of the estimation pair comparison of the individual expert it is not permissible to violate the coherence and logic of his estimations. A dual comparison excludes the possibility of "blind" use of an uncoordinated and illogical evaluation, requires its refinement or ignores the use of such an assessment. With the help of convenient and easy to use author's computer program, scientists were able to quickly obtain quantitative units of weighting factors of the studied components of a particular process. This allows to display all the results of an interdependent collective, logical and coordinated individual expert estimation.
RELATIONSHIP BETWEEN PERIODONTAL DISEASES AND COVID-19
(2023) Vynogradova, O.; Dyryk, V.; Мinko, L.; Danylchenko, S.; Данильченко, С. І.
The problem of the high prevalence of inflammatory and dystrophic periodontal diseases is very urgent, despite the high level of diagnostic and treatment technologies in the arsenal of dentists and the availability of information for patients [1]. According to professional literature, the prevalence of perio- dontal tissue pathology is 85-100%, and their presence causes a number of biochemical, immunological and functional disorders, microcirculatory and metabolic disorders, disorders of almost all types of metabolism develop: protein, lipid, mineral, carbohydrate, which leads to to the progressive destruction of tissues of the oral cavity [2]. Such a high prevalence of periodontal diseases, as well as their close relation- ship with somatic pathology, determine the importance of this problem. The presence of concomitant pat- hology, in particular, cardiovascular, endocrinological, autoimmune and viral diseases is a significant factor that determines the course and prognosis of periodontal tissue diseases [3]. At the end of 2019, the world faced a terrible epidemic - COVID-19, which is still an acute scientific, medical and social problem. The complexity of the coronavirus disease caused by SARSCoV-2 lies in the unpredictable clinical course of the disease, which can progress rapidly, causing severe and fatal compli- cations . The high prevalence of this infection makes it necessary to study its pathogenetic mechanisms[4] in order to prescribe timely therapy. The relationship between underlying comorbidities and periodontal pathology is reasonably well understood, and the relationship between COVID-19 and periodontitis is in critical need of additional research.
THE EFFECT OF PHYSICAL ACTIVITY ON THE SECRETORY FUNCTION OF MUSCLES AND BONE TISSUE IN HUMANS
(2023) Traverse, G.; Horoshko, V.; Danylchenko, S.; Траверсе, Г. М.; Горошко, В. І.; Данильченко, С. І.
The purpose of the study was to summarize new literature data on the effect of physical activity on the secretory function of skeletal muscles and their rela- tionship with organs. Materials and methods. Analytical methods were used in the study. The search for scientific information was carried out in databases of search systems. Results. Muscles secrete proteins called myok- ines, which are involved in a variety of processes by interacting with tissues. Current research has shown that exercise, by stimulating the skeletal muscle sys- tem in vivo, leads to the release of myokines and causes several effects that explain the positive effect of exercise in the treatment of several diseases of the musculoskeletal system. Skeletal muscles synthesize and secrete a wide range of myokines that contribute to various func- tions in organs, including the brain. Recent publica- tions have focused much attention on one such myo- kine, the recently discovered protein irisin, which is secreted into the bloodstream from skeletal muscle during exercise from the membrane-bound precursor fibronectin type III. Irisin promotes metabolic process- es such as glucose homeostasis and the darkening of white adipose tissue. Irisin also crosses the blood- brain barrier and initiates a neuroprotective genetic program in the hippocampus, which culminates in increased expression of brain-derived neurotrophic factors. Most studies report that irisin concentration is closely related to health status. For example, irisin levels are significantly lower in patients with obesity, osteoporosis/fracture, muscular atrophy, Alzheimer’s disease, and cardiovascular disease. Over the past decade, several myokines have been discovered, expanding our understanding of how muscles interact with other organs. In recent publications, a lot of attention is paid to the recently discovered protein irisin, which contributes to met- abolic processes. A series of studies on irisin have provided new insights into the mechanisms of exer- cise to improve bone density, counteract cartilage degeneration, and maintain overall joint environmen- tal homeostasis. These studies further contribute to the understanding of the role of exercise in the fight against osteoarthritis and may provide important assistance in advancing the prevention and treatment of this common disease. Research on the exercise-induced muscle factor irisin will help to better understand and explain the beneficial effects of exercise on maintaining physi- cal health, especially in the fight against aging and age-related degenerative changes. Conclusion. Thus, exercise-induced stimulation of bioactive cytokines increases muscle anabolism, bone formation, mitochondrial biogenesis, glucose utilization, and fatty acid oxidation, and reduces chronic inflammation. Метою дослідження було узагальнення нових літературних даних про вплив фізичної активності на секреторну функцію скелетних м’язів та її зв’язок з іншими органами. Матеріали і методи. У дослідженні використано аналітичний та бібліосемантичний методи. Пошук наукової інформації здійснювався в базах даних електронних пошукових систем. Результати. Сучасні дослідження показують, що фізичні вправи стимулюють скелетну мускулатуру in vivo, що призводить до вивільнення міокінів та спричиняє низку ефектів, які пояснюють позитивні ефекти фізичних вправ у лікуванні багатьох захворювань опорно-рухового апарату. Скелетні м’язи синтезують і виділяють різні міокіни, які сприяють різним функціям органів, включаючи мозок. Іризин, який був синтезований порівняно нещодавно, виділяється зі скелетних м’язів під час фізичних вправ. Іризин сприяє таким метаболічним процесам, як гомеостаз глюкози і потемніння білої жирової тканини. Іризин також долає гематоенцефалічний бар’єр і ініціює програму нейропротекторного гена в гіпокампі. Це збільшує експресію нейротрофічного фактора мозку. Більшість досліджень показали, що рівень іризину тісно пов’язаний зі станом здоров’я. Останні публікації приділили багато уваги нещодавно відкритому білку іризину, який сприяє метаболічним процесам. Серія досліджень щодо іризину дозволила по-новому зрозуміти механізми впливу на покращення щільності кісткової тканини, протидії дегенерації хряща та підтримки загального екологічного гомеостазу суглобів. Ці дослідження можуть додатково сприяти розумінню ролі фізичних вправ у боротьбі з остеоартритом і надати важливу підтримку в просуванні профілактики та його лікування. Висновок. Індукована фізичними вправами стимуляція біоактивних цитокінів збільшує анаболізм м’язів, формування кісток, мітохондріальний біогенез, утилізацію глюкози та окиснення жирних кислот, а також зменшує хронічне запалення. У перспективі розвитку дослідження іризину можуть краще пояснити сприятливий вплив фізичних вправ на підтримку фізичного здоров’я, особливо в боротьбі зі старінням і пов’язаними з віком дегенеративними змінами.
THE FEATURES OF EMERGENCY SURGICAL CARE DURING THE COVID-19 PANDEMIC
(2023) Zaiets, S.; Dudchenko, M.; Horoshko, V.; Prykhidko, R.; Kravtsiv, M.; Danylchenko, S.; Заец, С.; Дудченко, М.; Хорошко, В.; Кравцив, Н.; Данильченко, С.; Данильченко, С. І.
The article presents the results of a study conducted to analyze and determine the characteristics of providing emergency surgical care in the context of the COVID-19 coronavirus infection. A retrospective analysis of case histories of 242 patients with confirmed COVID-19 infection was conducted, who were admitted to the surgical department from February to June 2021 due to the need for emergency surgery. A comparative analysis was carried out with a group of patients who underwent emergency surgery from February to June 2019 (group without COVID-19 infection). Emergency surgical care for patients in an infectious diseases hospital was one of the urgent problems during the pandemic of a new coronavirus infection COVID-19. The analysis showed that during the pandemic period, the number of patients with American Society of Anesthesiologists status 2-3 was significantly higher (< 0.0001), and the mortality rate during the pandemic period in the surgical department was 6.2%. During the pandemic, we detected the prevalence of patients with pathologies related to coagulopathy due to COVID-19 infection in the form of thrombosis of the mesenteric arteries, thrombosis of the arteries of the lower extremities, perianal venous thrombosis, and thrombophlebitis. The tendency for thrombosis and the development of coagulopathy in patients with COVID-19 infection should be taken into account when preparing them for surgery and preventing thrombosis with the help of anticoagulants. Laparoscopic operations are safe for medical personnel, providing the compliance with sanitary and epidemiological requirements. В статье представлены результаты исследования, проведенного с целью анализировать и определить особенности оказания неотложной хирургической помощи в условиях коронавирусной инфекции COVID-19. Был проведен ретроспективный анализ медицинских карт 242 пациентов с подтвержденной инфекцией COVID-19, поступивших в хирургическое отделение Полтавской городской клинической больницы №3, с февраля по июнь 2021 г. в связи с необходимостью экстренного оперативного вмешательства. Сравнительный анализ проведен с группой пациентов, перенесших экстренную операцию в период с февраля по июнь 2019 г. (группа без инфекции COVID-19). В результате проведенных исследований установлено, что в период пандемии количество больных со статусом American Society of Anesthesiologists 2-3 было достоверно выше (< 0,0001), а летальность в период пандемии в хирургическом отделении составила 6,2%. В период пандемии выявлено преобладание пациентов с патологией, связанной с коагулопатией на фоне инфекции COVID-19, в виде тромбоза мезентериальных артерий, тромбоза артерий нижних конечностей, перианального венозного тромбоза, тромбофлебита. По мнению авторов, следует учитывать склонность к тромбообразованию и развитию коагулопатии у пациентов с инфекцией COVID-19 при подготовке их к операции и профилактике тромбообразования с помощью антикоагулянтов.
КЛІНІЧНА ЕФЕКТИВНІСТЬ КОМПЛЕКСНОЇ КОНСЕРВАТИВНОЇ ТЕРАПІЇ ХВОРИХ НА ГОНАРТРОЗ
(2021) Маколінець, В. І.; Маколінець, К. В.; Морозенко, Д. В.; Данильченко, С. І.; Makolinets, V.; Makolinets, K.; Morozenko, D.; Danylchenko, S.
У статті розглянуто питання оцінки ефективності трьох схем консервативного лікування хворих на гонартроз. Найкращий результат було отримано у пацієнтів, яким спочатку проводили опромінення колінних суглобів низькоінтенсивним лазерним випромінюванням, а потім через 30–40 хвилин застосовували глюкозаміну гідрохлорид та диклофенак калію. Саме така послідовність застосування лікувальних засобів виявлялась найбільш ефективною у комплексній терапії пацієнтів за гонартрозу. The article considers the issue of evaluating the effectiveness of three schemes of conservative treatment of patients with knee osteoarthritis. The best results were obtained in patients who were first irradiated with low-intensity laser radiation to the knee joints, and then after 30–40 minutes glucosamine hydrochloride and diclofenac potassium were used. This sequence of treatment was the most effective in the complex therapy of patients with knee osteoarthritis.