Browsing by Author "Morozenko, D."

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    DYNAMICS OF BIOCHEMICAL MARKERS OF THE CONNECTIVE TISSUE METABOLISM IN THE BLOOD OF RATS AFTER INSERTION OF STEEL IMPLANTS WITH DIAMOND-LIKE CARBON COATING INTO THE FEMUR
    (2021) Makarov, V.; Morozenko, D.; Gliebova, K.; Danylchenko, S.; Данильченко, С. І.
    Objective: It is known that the regeneration of bone tissue after implantation of any structures depends on the coating of their surface. Therefore, the research of the influence of steel implants with diamond-like carbon coating on regeneration of bone tissue in the dynamics after implantation is a topical issue. Material and Methods: The study was conducted on 61 male rats, 5 of them were intact animals. There were also 2 groups of rats with 28 animals in each group (the 1 st group was the control one where implants were without diamond-like carbon coating, the 2 nd group was experimental where the implants were without coating). We determined the content of glycoproteins, chondroitin sulfates, alkaline phosphatase, total calcium, oxyproline and osteocalcin in the blood of rats on the 7th , 14th, 30th and 90th days after implantation. Results and Discussion: Group 2 rats had a faster osteointegration compared with the group 1 rats, which was manifested by the normalization of biochemical markers of bone metabolism (glycoproteins, chondroitinsulfats, oxyproline and osteocalcin) on the 90th day of an experiment. Conclusion: Using steel implants with diamond-like carbon coatings showed that the content of glycoproteins and chondroitin sulfates increased only on the 7th day; oxyproline and osteocalcin increased on the 7th , 14th and 30th days after implantation; on the 90th day the rates of these biochemical markers reached the norm, indicating a high efficiency of osteointegration.
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    КЛІНІЧНА ЕФЕКТИВНІСТЬ КОМПЛЕКСНОЇ КОНСЕРВАТИВНОЇ ТЕРАПІЇ ХВОРИХ НА ГОНАРТРОЗ
    (2021) Маколінець, В. І.; Маколінець, К. В.; Морозенко, Д. В.; Данильченко, С. І.; Makolinets, V.; Makolinets, K.; Morozenko, D.; Danylchenko, S.
    У статті розглянуто питання оцінки ефективності трьох схем консервативного лікування хворих на гонартроз. Найкращий результат було отримано у пацієнтів, яким спочатку проводили опромінення колінних суглобів низькоінтенсивним лазерним випромінюванням, а потім через 30–40 хвилин застосовували глюкозаміну гідрохлорид та диклофенак калію. Саме така послідовність застосування лікувальних засобів виявлялась найбільш ефективною у комплексній терапії пацієнтів за гонартрозу. The article considers the issue of evaluating the effectiveness of three schemes of conservative treatment of patients with knee osteoarthritis. The best results were obtained in patients who were first irradiated with low-intensity laser radiation to the knee joints, and then after 30–40 minutes glucosamine hydrochloride and diclofenac potassium were used. This sequence of treatment was the most effective in the complex therapy of patients with knee osteoarthritis.