Факультет біології, географії та екології
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Item Effect of Interleukin-2 on the humoral link of immunity during physical activity(2020) Shvets, V.; Shkuropat, A.; Prosiannikova, Ya. M.; Golovchenko, I. V.; Просяннікова, Я. М.; Швець, В. А.; Шкуропат, А. В.; Головченко, І. В.The effect of physical activity can be considered as a prototype of stress with all the shifts in hormonal and immune systems that are inherent in the body’s response to stress. The aim of this study was to evaluate the level of immunoglobulins during the process of adaptation to physical activity under conditions of stimulation and inhibition of interleukin-2 (IL-2). Five groups of mice were organized. Group 1 received an inhibitor of IL-2, Groups II, III and IV received IL-2 at concentrations of 5000, 7500 and 30,000 IU/kg, respectively, Group V received physiological saline only. The method of forced swimming was used as physical training. To determine the effect of IL-2 on humoral immunity during adaptation to physical training, blood levels of adrenaline, IgG, IgA and IgM were determined. In all groups anadrenaline concentration increased owing to physical activity. Furthermore, animals receiving IL-2 showed a higher level of adrenaline than animals in other experimental groups. This effect was dose-dependent. The IgG level increased in mice that received IL-2 while exercising. IgA and IgM levels remained independent of IL-2 stimulation, although the IgA level slightly varied in mice that received an inhibitor of IL-2. In all experimental groups IgA and IgM levels decreased irrespective of IL-2 stimulation and inhibition, the decrease was caused by physical training only. Blood tests of animals from all experimental groups showed a change in the ratio of immunoglobulins, that is an increase in the relative content of IgG during physical training and a decrease in the relative content of IgA and IgM.Item Regulation Of The Immune Response In The Children Aged 7-11 Years With Chronic Sensorineural Hearing Loss(2012) Beschasnyi, S. P.; Gasiuk (Hasiuk), E.; Бесчасний, С. П.; Гасюк, О. М.Показано, що діти 7-11 років із сенсоневральною приглцхцватісттю мають підвищений рівень в сечі адреналіну та 17 кетостероїдів. Це є маркером стресової реакції. Падалі активується імунна система. Змінюються біохімічні показники лейкоцитів. Активовані лейкоцити вивільняють протизапальні інтерлейкіни. Ми спостерігали підвищені рівні IgA і IgG в крові, а також зниження рівня IgM. У слині спостерігали високий рівень IgG і зниження рівнів IgA і IgM. Це призводить до зниження неспецифічного імунітету у дітей із порушеннями слуху. It has been shown that children 7-11 years of age with sensory urethral hypoglycavitis have elevated serum levels of adrenaline and 17 ketosteroids. This is a marker of stress response. Padali activates the immune system. The biochemical parameters of leukocytes are changing. Activated leukocytes release anti-inflammatory interleukins. We observed elevated levels of IgA and IgG in the blood, as well as a decrease in IgM levels. In saliva, high levels of IgG and a decrease in IgA and IgM levels were observed. This leads to a decrease in nonspecific immunity in children with hearing impairment.