ІНДИВІДУАЛЬНІ КОЛЕКЦІЇ ВИКЛАДАЧІВ ТА СПІВРОБІТНИКІВ
Permanent URI for this communityhttps://ekhsuir.kspu.edu/handle/123456789/66
Browse
10123 results
Search Results
Item LABORATORY MARKERS FOR OVERLOAD OF THE CERVICAL SPINE(2025) Leontieva F. S.; Fedotova I. F.; Morozenko D. V.; Danylchenko S. I.Recently, the number of applications from patients who have significant physical exertion in conditions of prolonged exposure to stress factors has increased significantly. Spinal overload is a rather serious and important factor that contributes to the development of degenerative changes, as well as metabolic disorders of various kinds that occur in conditions of chronic stress. In clinical and fundamental medicine, most of the clinical and pathophysiological changes in the human body that occur under the influence of chronic stress and contribute to the development of metabolic disorders during spinal overload remain incompletely understood. This problem is especially important and relevant today for the military, who, during the difficult fight against armed aggression in conditions of chronic stress, have significant physical exertion, which is reflected in the condition of the spine. The aim of the study is to identify the most modern laboratory markers of metabolic disorders during spinal overload. Materials and methods. The scientific data of the PubMed platform for 2021– 2025 were analysed. Results The dynamics of clinical and functional disorders in the body of patients with cervical spine overload on the background of chronic stress includes a complex of structural, functional changes and neurological disorders, which in the case of a long course lead to the development of degenerative diseases of the spine. The conceptual scheme of the formation of metabolic disorders in patients with cervical spine overload on the background of chronic stress consists in the consistent and gradual development of clinical and metabolic disorders, which are reflected in structural and functional changes and clinical and laboratory indicators of blood and urine. The direction of research on the development of criteria for assessing and preventing the impact of chronic stress on the human body with spinal overload can be considered promising. Among the most informative markers that can be used to examine patients are the following: C-reactive protein (may increase in the blood due to inflammation of muscle tissue and/or ligaments in the neck area), integral leukogram indicators (changes in the ratio of leukocytes – leukocytosis, lymphocytopenia or neutrophilia may be detected in patients as reactions to stress); interleukin-1 (often increases in the blood during chronic stress and is associated with inflammation), as well as interleukin- 10 (has an anti-inflammatory effect and may decrease during chronic stress). Conclusions. The most effective laboratory markers for assessing the condition of patients with cervical spine overload on the background of chronic stress can be considered inflammatory markers, marker enzymes for assessing muscle tissue, indicators of insulin resistance, hormonal metabolism and interleukins.Item PERSONALIZED REHABILITATION STRATEGIES FOLLOWING LOWER LIMB AMPUTATION: CLINICAL AND FUNCTIONAL OUTCOMES(2025) Danylenko A. S.; Danylchenko S. I.; Fursenko A. О.; Morozenko D. V.; Chorna I. O.Objective. The objective of this study was to evaluate the effectiveness of a physical rehabilitation protocol for patients following lower limb amputation, taking into account prosthetic fitting specifics and gait skill development. Materials and Methods. The study included 20 patients with transtibial amputations. The rehabilitation program integrated therapeutic exercise, physiotherapy, massage, robotic-assisted technologies, and psychological support. Effectiveness was assessed using indicators of muscle strength, balance, coordination, functional mobility, and quality of life. Results. Implementation of the program led to significant improvements in rehabilitation outcomes. Patients demonstrated measurable gains in lower limb muscle strength, enhanced postural control, improved coordination, and better walking parameters. Average gait speed increased by more than 20%, and step length and cadence became more symmetrical compared to baseline. In the 6-Minute Walk Test, patients extended their average walking distance from 260 m at baseline to 320 m after completing the program, indicating greater endurance. Balance performance also improved, with mean Berg Balance Scale scores rising from 42 to 48 points, reflecting more stable mobility. Functional mobility scores increased across all amputation levels, with transtibial amputees showing the most pronounced progress. Importantly, the structured protocol reduced rehabilitation duration by approximately 3 weeks on average and facilitated earlier adaptation to the prosthesis. Psychological support played a crucial role in helping patients overcome fear of falling, enhancing motivation, and promoting consistent use of the prosthesis in daily life. Overall, the combined multidisciplinary approach ensured higher mobility levels, faster reintegration into daily activities, and substantial improvements in self-reported quality of life across both physical and psychosocial domains. Conclusions. The proposed rehabilitation program proved effective for optimizing recovery after lower limb amputation. Its application in clinical practice can improve functional outcomes and quality of life and may be recommended for wider use in rehabilitation services.Item PHARMACOGENETIC ASPECTS OF THERAPY FOR AUTOIMMUNE HEPATITIS AGAINST THE BACKGROUND OF DEGENERATIVE-DYSTROPHIC JOINT LESIONS.(2025) Borysenko T. V.; Babalian V. O.; Dorofieieva V. R.; Danylchenko S. I.; Fedota О. М.Introduction and aim. The pathogenesis of autoimmune diseases, including musculoskeletal, gastrointestinal, and endocrine manifestations, involves the interaction of genotype and environmental factors. Pathologies demonstrate comorbidity and clinical heterogeneity even within a single family. Genetic polymorphisms of one-carbon metabolism are key regulators of cel- lular processes that become therapeutic targets. Description of the case. The study describes personalized therapy for a patient with an autoimmune comorbid disease, with an emphasis on genetic and metabolic characteristics. The treatment regimen is adapted to the features of the one-carbon metabolism profile of a patient with chronic autoimmune hepatitis and degenerative-dystrophic joint disease. Family history includes autoimmune thyroiditis, vitiligo, Parkinson’s disease, cardiovascular diseases. The patient’s genotype for single nucleo- tide polymorphisms rs1801133, rs1801131, rs1801394, rs1805087, and rs3733890 of the one-carbon metabolism genes is asso- ciated with elevated plasma homocysteine levels. After treatment, changes in biochemical parameters were observed: alanine aminotransferase (72→53 U/L), aspartate aminotransferase (53→44 U/L), gamma-glutamyltransferase (129→89 U/L), alkaline phosphatase (313→125 U/L) and homocysteine (15.1→17.0 μmol/L). Conclusion. Positive dynamics after personalized therapy demonstrates the importance of an interdisciplinary approach to etio- pathogenetic treatment, emphasizing the need to support hepatobiliary function along with muscular and skeletal therapy.Item MAGNETOELECTROCHEMICAL THEORY OF METABOLISM AND LIFE IS A NEW TREND IN COMPLEXITY IN HEALTH SCIENCES(2025) Nevoit G.; Poderiene K.; Danylchenko S.; Kitura O.; Liulka N.; Golovchenko I.; Potyazhenko M.; Mintser O.; Jarusevicius G.; Vainoras A.In 2018, research was initiated to investigate the role of electromagnetic processes in human metabolism. This theoretical research is part of the research work of the Department of Internal Medicine and Emergency Medicine of Poltava State Medical University (23, Shevchenko St., 36011, Poltava, Ukraine) on “Development of algorithms and technologies for implementing a Healthy Lifestyle in patients with Non-Communicable Diseases (NCDs) based on the study of functional status” (state registration number 0121U108237: UDC 613 616-056-06: 616.1/9-03). The results of this work were embodied in the conceptualization of the Magnetoelectrochemical Theory of Metabolism and Life. The purpose of this article is to present to the academic community brief information about the results of the research work carried out in this direction for the further development of these scientific ideas and their integration into the scientific paradigm. Conclusions: 1) Magnetoelectrochemical Theory of Metabolism and Life is a new trend in Complexity in Health Sciences. 2) The biophysical direction of development of modern medicine opens up new ways to solve the problems of diseases of internal organs. 3) Knowledge of the fundamental aspects of electromagnetic communication of cells of the human body is a new basis for deepening the fundamental knowledge of the pathogenesis of diseases of internal organs, and this is a new promising direction for further research. 4) Bioelectronic Medicine, as a new component of medical science, is based on and directs therapeutic influence on the quantum levels of the structure and functioning of the human body. 5) The initiative educational and scientific project “Bioelectronic Medicine or Look at Medicine Differently” is a practical attempt in the conditions of the scientific present to find a way to change the scientific paradigm and popularize the latest knowledge among the academic community of the biomedical direction. 6) The practical application of this knowledge opens up new avenues for the further development of Magnetobiology, Internal Medicine, Microbiology, and Traditional Medicine. It can ensure progres in the treatment of diseases of internal organs, whether infectious or non-infectious in origin.Item HOW ARTICLES ARE PREPARED FOR PUBLICATION IN THE SCIENTIFIC JOURNALS OF THE KHARKIV NATIONAL(2025) Nakonechna O. A.; Shevchenko A. S.; Danylchenko S. I.; Korneiko I. V.Kharkiv National Medical University (KhNMU) is the founder and publisher of periodical (quarterly) peer-reviewed scientific journals of open access "Medicine Today and Tomorrow" (ISSN print 2414-4495, ISSN online 2710-1444), "Experimental and Clinical Medicine" (ISSN print 2414-4517, ISSN online 2710-1487) and "Inter Collegas" (ISSN online 2409- 9988). We have analyzed the work with manuscripts of articles of these journals and present readers with a detailed description of the procedures that should help the authors of articles to effectively cooperate with the editors of these scientific journals in preparing their articles for publication. The article will also be useful to members of editorial boards and editorial councils of journals. This publication will help article reviewers determine their readiness for the procedure. We described both the existing rules and procedures for working with manu- scripts, as well as the changes that will come into force from the beginning of July 2025. The article describes the structure of the manuscript, issues of ethics of the researcher and author, copyright, plagiarism checking, reviewing and editing of manuscripts, the policy of the jour- nal in cases of violation of ethics, the mission of the journals. The editorial board uses a double blinded peer review procedure with the participation of at least two reviewers for each article. Reviewers are invited by editors. The reviewers have the appropriate specialization and ex- perience in the subject matter of the articles they propose. The editorial board is loyal to the lack of experience of young authors, but is intolerant of falsification of research results and plagiarism, creating conflict situations while working on manuscripts. The publication of ar- ticles and their further use is under the terms of the Creative Commons license (BY-NC-SA). The editorial board relies on the principles of evidence-based medicine and publishes articles that contain contradictory issues from the point of view of evidence with a note about their disagreement with the position of the authors.Item FEATURES OF DIAGNOSTICS OF FATAL KIDNEY INJURY IN MEDICAL PRACTICE(2025) Babkina O.; Danylchenko S.; Korobko I.; Yanchevskyi O.; Kravchenko A.Aim: To examine how temperature changes over time in injured and uninjured kidney tissues, based on the time elapsed since trauma and death. Additionally, develop a regression model to estimate the time of death using temperature measurements from the abdominal organs. Material and Methods: The study included data from 256 individuals (both males and females aged 20–60 years) who died from mechanical trauma. Tissue temperatures were measured using infrared thermometry at various times within 24 hours after death. The analysis covered temperature measurements of the liver, spleen, pancreas, kidneys, skin, and the thickness of subcutaneous fat tissue. Results: Determining the exact time of death remains a complex aspect of forensic practice, especially in cases involving traumatic injuries. Often, the moment of injury does not match the time of death: the person may die immediately at the scene or after some delay—during transport or at a medical facility. Therefore, distinguishing between the “time of injury” and the “time of death” is crucial for accurate forensic evaluation. A statistically significant decrease in temperature was observed in both injured and uninjured kidney tissues. The temperature in the injured areas stayed consistently higher by 2–3 °C (±0.28) compared to uninjured regions. The temperature difference between the right and left kidneys was 1.5–2 °C (±0.14), likely due to anatomical factors that offer greater protection to the right kidney. The sex of the deceased did not affect temperature indicators. A regression model was created to estimate the time of death with high accuracy (R² = 0.86), including temperatures of several parenchymal organs, skin temperature, subcutaneous fat thickness, and ambient temperature. All predictors in the model were statistically significant (p < 0.05). Conclusions: The developed multivariate regression model, which considers temperature parameters of injured and uninjured parenchymal organs, serves as a promising tool for forensic estimation of the time of death. Our study's findings emphasize the potential of infrared thermometry in forensic practice as a quantitative method for determining the post-injury interval and the time of death.Item ВИМОГИ ДО ОФОРМЛЕННЯ РУКОПИСІВ НАУКОВИХ СТАТЕЙ ЖУРНАЛІВ ХАРКІВСЬКОГО НАЦІОНАЛЬНОГО МЕДИЧНОГО УНІВЕРСИТЕТУ (ДІЮТЬ ВІД 01.07.2025).(2025) Шевченко О. С.; Данильченко С. І.Item ПОРЯДОК РОБОТИ ЗІ СТАТТЯМИ НАУКОВИХ ЖУРНАЛІВ ХАРКІВСЬКОГО НАЦІОНАЛЬНОГО МЕДИЧНОГО УНІВЕРСИТЕТУ(2025) Наконечна О. А.; Шевченко О. С.; Данильченко С. І.; Корнейко І. В.Ця методична стаття присвячена опису внутрішніх процедур роботи з рукописами ав- торів протягом 2021–2024 років в редакції наукових журналів Харківського Національ- ного Медичного Університету (ХНМУ), яка готує до публікації статті в журнали «Меди- цина сьогодні і завтра» (ISSN 2414-4495, 2710-1444), «Експериментальна і клінічна ме- дицина» (ISSN 2414-4517, 2710-1487) та "Inter Collegas" (ISSN 2409-9988). Процедура роботи з рукописами є важливою для авторів статей, редакторів, рецензентів, членів ре- дакційних колегій та редакційних рад, керівників спеціалізованих рад із захисту дисер- тацій в українських закладах вищої освіти та науково-дослідних установах. В статті опи- сані як чинні алгоритми роботи із рукописами та опублікованими статтями, так і зміни, що планує внести до цих алгоритмів редакція наукових журналів у 2025 році. Стаття має сприяти покращенню розуміння вимог до рукописів, зокрема описування авторами про- ведених наукових досліджень з дотриманням принципів доброчесності дослідника та вченого, принципів доказової медицини, етики автора, рецензента та редактора. Для цього у редакції застосовуються процедури обов’язкової перевірки текстів на плагіат, процедура подвійного засліпленого рецензування рукописів за участю як мінімум двох рецензентів, вибору рецензентів відповідного профілю та кваліфікації для кожного ру- копису, редагування рукописів редакторами з медичною освітою, публікація на умовах ліцензії Creative Commons. Редакція не толерантна до випадків грубих та неодноразових порушень етики авторів та рецензентів, до фальсифікації результатів наукових дослід- жень та плагіату. Алгоритми роботи із рукописами та опублікованими статтями в науко- вих журналах ХНМУ сприяють вільному висловленню наукової думки та поширенню наукової інформації завдяки політиці негайного відкритого доступу до опублікованого змісту.Item PHYSICAL THERAPY IN GERONTOLOGY: OPPORTUNITIES FOR ENHANCING QUALITY OF LIFE AMID POPULATION AGEING(2025) Khan A. Yu.; Tarasova O. O.; Danylchenko S. I.; Golovchenko I. V.; Morozenko D. V.This review article examines current approaches to physical therapy in gerontological practice aimed at preserving functional independence and improving quality of life in adults aged 65 and older. Demographic trends toward an increasing proportion of older individuals present healthcare systems with new challenges, notably the prevention of non-communicable diseases, the reduction of fall risk, and the mitigation of rapid functional decline. Regular adaptive physical activity – including aerobic, resistance, balance, and yoga exercises – has been shown to significantly lower the risk of cardiovascular disease, osteoporosis, and type 2 diabetes, while also enhancing cognitive function and psycho emotional well-being (SMD (Standardized Mean Difference) ≈ 0.5 for cognitive reserve; SMD ≈ –0.6 for anxiety reduc- tion). Individualized exercise programs that combine aerobic and strength training yield sta- tistically significant improvements in functional status, reductions in depressive symptoms, and increases in self-esteem. A dedicated section addresses non-pharmacological modalities such as therapeutic massage, physical agents (galvanic current, electrophoresis, ultrasound, magnetotherapy), respiratory and inhalation techniques, short wave diathermy, and low am- plitude electrical stimulation. These interventions effectively relieve pain, improve microcir- culation, reduce muscle tension, and promote tissue healing in degenerative dystrophic con- ditions. Significant attention is given to emerging technologies – tele physiotherapy, wearable sensors, virtual reality, biofeedback, and transcranial magnetic stimulation which facilitate remote monitoring, personalize interventions, and expand rehabilitation access for individuals with limited mobility. A multidisciplinary team approach is essential for developing compre- hensive plans that address patients’ physical, cognitive, and psychosocial needs. The article concludes by emphasizing the need to integrate innovative physiotherapeutic strategies into primary care, strengthen the evidence base, and enhance professional training.Item COMPREHENSIVE REHABILITATION OF OLDER ADULTS FOLLOWING ACUTE STROKE: EMPHASIS ON THERAPEUTIC EXERCISES AND THE MULTIDISCIPLINARY APPROACH(2025) Salii A. O.; Danylchenko S. I.; Golovchenko I. V.; Tarasova O. O.; Morozenko D. V.Background. Stroke remains one of the leading causes of long-term disability worldwide, especially among older adults. Given the increasing incidence of CerebroVascular Accidents (CVAs) in the aging population, there is a growing need for comprehensive, individualized reha- bilitation programs that address the specific physical, cognitive, and emotional needs of elderly patients. Aim. To evaluate the effectiveness of therapeutic exercise as part of a multidisciplinary reha- bilitation approach in elderly patients following an acute stroke. Materials and Methods. The study included 21 patients aged 62 to 79 years who were under- going rehabilitation following an acute CVAs in a district hospital setting. The rehabilitation pro- cess featured a seven-stage individualized program consisting of physical therapy, occupational therapy, speech and language therapy, cognitive training, and psychosocial support. The effec- tiveness of the interventions was evaluated using standardized scales: the Modified Rankin Scale, Barthel Index, Montreal Cognitive Assessment, Visual Analogue Scale, and Borg Rating of Per- ceived Exertion. Results. 76% of the participants (n=16) showed significant improvement in their overall con- dition, including reduced neurological symptoms (aphasia, hemiplegia), enhanced motor skills, better balance, improved emotional well-being, and increased independence in daily activities. The remaining 24% of patients (n=5) also demonstrated positive changes but required additional rehabilitation cycles due to limited recovery potential and complex comorbidities. Conclusions. Individualized therapeutic exercises, integrated within a multidisciplinary reha- bilitation framework, are effective in improving the physical and cognitive outcomes of elderly patients after stroke. Early initiation of rehabilitation, combined with continuous assessment and support from a multidisciplinary team, enhances functional recovery and improves the overall quality of life in this vulnerable population.