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30 РОКІВ ПІСЛЯ ЧОРНОБИЛЯ: УРОКИ ТА ПЕРСПЕКТИВИ
(2016) Попович, Т. А.; Вишневська, Л. В.; Міщенко, Г. В.
30 РОКІВ ПІСЛЯ ЧОРНОБИЛЯ: УРОКИ ТА ПЕРСПЕКТИВИ
(2016) Попович, Т. А.; Вишневська, Л. В.; Міщенко, Г. В.
ANALYSIS AND ASSESSMENT OF ARTIFICIAL INTELLIGENCE POTENTIAL FOR IMPROVING AND AUTOMATING THE DEVELOPMENT OF METHODOLOGICAL SUPPORT FOR THE EDUCATIONAL PROCESS IN DISTANCE LEARNING
(2025) Reshnova S.; Vasylieva N.; Popovych T.; Pylypchuk L.; Solona Yu.
This article analyzes the potential of artificial intelligence (AI) to enhance and partially automate the development of methodological support for distance education. The growing demand for quality digital content and the rapid integration of AI in education underline the relevance of this research. Special focus is placed on AI-generated educational materials, particularly glossaries and explanatory resources in biochemistry. The study highlights both advantages and limitations of AI in generating definitions of biochemical terms. For instance, the AI-generated definition of glucose lacks essential scientific details, such as its molecular structure and role in metabolism. Similarly, the description of monosaccharides omits key chemical characteristics, limiting their academic value. These examples raise concerns about the scientific adequacy of AI-generated content. Nevertheless, the article emphasizes the benefits of AI in expediting initial content creation, aiding information synthesis, and reducing educator workload. However, mandatory expert review is required to ensure high academic quality. The analysis of glossaries also revealed significant gaps, particularly the absence of terms related to the classification of carbohydrates, enzymatic activity, metabolic processes, and other key concepts of biochemical relevance. In conclusion, the study advocates for a hybrid approach that combines AI’s efficiency with expert oversight to produce accurate and pedagogically valuable materials. Based on the findings, practical recommendations are provided for effectively integrating AI tools into the development of methodological resources for scientific distance learning.
ANGIOGENESIS, TISSUE HYPOXIA AND OXIDATIVE STRESS DURING MOTOR ACTIVITY OF VARIOUS DIRECTIONS AND INTENSITY
(2024) Gunina, L. M.; Orlov, A.; Danylchenko, S. I.; Golovashchenko, R.; Данильченко, С. І.
The study of the mechanisms of OS- induced effects with typical of it hypoxia-induced gene expression, is important in searching criteria for evaluation and prediction of physical efficiency. Recent studies have shown that oxygen-sensitive protein complex with transcriptional activity, namely hypoxia-induced factor (HIF-1α) plays the key role in the process of maintaining balance between the need for oxygen in living cells and its delivery. In mammals, HIF-1α is considered a leading inducer of transcription gene expression which responds to the lack of oxygen. HIF-1α is activated in physiologically important sites of oxygen pathway regulation, providing quick and adequate response to hypoxic stress, and, in particular, the expression of genes controlling the formation and growth of new blood vessels.
ANTISTRESS ACTIVITY OF OLYGOSACCARINES IN PLANTS
(2001) Volkova (Pylypchuk), L. L.
APPROACHES TO PHARMACOLOGICAL CORRECTION Of PSYCHOPHYSIOLOGICAL STRESS IN ATHLETES
(2021) Gunina, L. M.; Vysochina, N. L.; Danylchenko, S. I.; Mikhalyuk, E. L.; Voitenko, V. L.; Гунина, Л. М.; Высочина, Н. Л.; Данильченко, С. И.; Михалюк, Е. Л.; Войтенко, В. Л.; Данильченко, С. І.
The aim of the study was to assess the effectiveness of the in- fluence of the medical drug tivortin®aspartate (drinking solution of l-arginine aspartate) on the psychophysiological characteris- tics and the severity of psychophysiological stress in qualified athletes at the stage of direct preparation for the competition. Methodologically, the studies, which are randomized, blind, placebo-controlled, during the course (14 days) of drug usage in a daily dose of 40 ml were carried out in compliance with bio- ethical principles. the athletes in the control subgroups received placebo (3% glucose solution) in identical dosage, multiplicity and duration of usage. the assessment of the severity of psycho- physiological stress and its individual components was carried out in a technology modified by us according to the standard questionnaire of V.a. ivanchenko. the results obtained showed that in both control subgroups by the end of the observation period, although not too sig- nificant, but nevertheless, a significant increase in the value of the magnitude of psychophysiological stress was observed (from 38.08±1.38 to 41.67±1.71 points and from 37.52±1.24 to 39.94±0.99 points for athletes and weightlifters, respec- tively; in both cases changes are valid, p <0.05) and its indi- vidual components. On the contrary, in the athletes who used tivortin®aspartate in the dynamics of the study, the indicators of the severity of psychophysiological stress very significantly and reliably (from 48.67±0.69 to 39.17±1.07 in athletes and from 41.14±0, 46 to 39.97±0.79 in weightlifters; in both cases chang- es are valid, p <0.05) decreased, which indicated an improve- ment in psychological stability and a corresponding increase in mental stability to the forthcoming impact of competitive loads. In this way, the data obtained indicate an improvement in the mental readiness of athletes for the upcoming competitions and substantiate the advisability of using pharmacological substances based on l-argi- nine to improve psychophysiological characteristics during physical exertion with a different mechanism of energy supply. Целью исследования явилась оценка эффективности влияния препарата тивортин®аспартат (питьевой раствор L-аргинина аспартата) на психофизиологические характе- ристики и выраженность психофизиологического стресса у квалифицированных спортсменов на этапе непосредствен- ной подготовки к соревнованиям. Методологические исследования, по дизайну представ- ляющие собой рандомизированные слепые плацебо-кон- тролируемые, в динамике курсового (14 дней) применения препарата в суточной дозе 40 мл проводили с соблюдением биоэтических принципов. Плацебо (3% раствор глюкозы) спортсмены в контрольных подгруппах получали в иден- тичной дозировке, кратности и длительности применения. Оценку выраженности психофизиологического стресса и его отдельных компонентов проводили по модифициро- ванной авторами технологии по стандартному вопроснику В.А. Иванченко. Полученные результаты показали, что в обеих контроль- ных подгруппах к концу периода наблюдения выявлено хотя и не слишком значительное, однако достоверное увеличе- ние значения величины психофизиологического стресса (c 38,08±1,38 до 41,67±1,71 баллов и с 37,52±1,24 до 39,94±0,99 балла у легкоатлетов и тяжелоатлетов, соответственно) и его отдельных компонентов, а у спортсменов, применяв- ших в динамике исследования тивортин®аспартат, показа- тели выраженности психофизиологического стресса весь- ма значительно и достоверно снижались с 48,67±0,69 до 39,17±1,07 у представителей легкой атлетики и с 41,14±0,46 до 39,97±0,79 – у тяжелоатлетов, что указывает на улучше- ние психологической стабильности и соответствующее по- вышение психической устойчивости к предстоящему воз- действию соревновательных нагрузок. Таким образом, полученные данные указывают на улуч- шение психологической готовности спортсменов к пред- стоящим соревнованиям и обосновывают целесообразность применения фармакологических субстанций на основе L-аргинина для улучшения психофизиологических характеристик при физических нагрузках с разным механизмом энергообеспечения.
AROMATHERAPY IN THE TREATMENT OF SEASONAL RESPIRATORY VIRAL INFECTIONS
(2023) Yashchyshyn, Z. M.; Horoshko, V. I.; Danylchenko, S. I.; Ящишин, З. М.; Горошко, В. І.; Данильченко, С. І.
To determine the quality of the oil, it is necessary to conduct a number of complex laboratory studies, including a gas chromatographic analysis of the composition. This test is costly and will often not be carried out by users of aroma oils (private patients, doctors, rehabilitators, etc.). Although there is such equipment for diagnosing the charac- teristics of the oil, there is no standard database against which to compare the composition of the oil. The aim of this trial is to inform practitioners and consumers about the rules to be observed when working with EO and possible side effects with the help of modern gadgets. Methods. To achieve the set goals and solve certain problems, the following research methods were used, in particular: problem-chronological - to establish the chronology of the scientific study of the use of aromatherapy; socio- logical - a study of the medical and social qualities of the spread of pathological changes in the autonomic nervous system; analytical - to determine scientific guidelines, the use of evidence-based medicine in aromatherapy procedures; the method of terminological analysis, which made it possible to ensure the disclosure of the essence of the phenomena under study; the method of scientific extrapolation, which made it possible to determine the possibilities of creating and applying aromatherapy as an optimal synthesis of theoretical and practical knowledge; methods of multivariate statistical analysis and forecasting for data processing. Project objectives: 1. Develop a classification of EM, taking into account the standardization of requirements for them. 2. To study data on the effect of aerosol therapy with natural essential oils on the microbial and viral background of the body. 3. Analyze changes in cellular and humoral immunity before and after aerosol therapy with natural essential oils. 4. Develop a methodology and algorithm for conducting aerosol therapy with natural essential oils, and create a database for EO. 5. To study the clinical effectiveness of aerosol therapy with natural essential oils in complex rehabilitation. Results. The developed database will make it easy to navigate a huge variety of proposed types of essential oils and will allow you to establish its correspondence with the producing plant, which, unfortunately, cannot always be observed in essential oils offered for sale. Moreover, the aromatic oils included in the base must be checked for toxicity and correct use. Misuse may result in side effects, including allergic reactions, narcotic, carcinogenic or neurotoxic ef- fects. This database is created with the possibility of constant updating and adding new information in all its forms, is the initial stage of creating a more complete version and can be claimed by interested organizations, and individuals via the Internet. Conclusions. It is advisable to use phytoaeroprophylaxis in medical institutions (hospitals, medical units, health centers, sanatoriums, maternity hospitals, nursing homes, etc.). Of course, a return to natural remedies, in particular to aerophytotherapy, and phytoaeroprophylaxis, should be combined with the study of their action at the modern methodo- logical level, thorough clinical development of indications and contraindications for their use. Сучасна ароматерапія – профілактичний, оздоровчий, повністю природний спосіб, який ефективно застосовується в практиці фізичної реабілітації. Мета. Поінформувати практиків і споживачів про правила роботи з ефірними оліями та можливі побічні ефекти за допомогою сучасних гаджетів. Матеріали і методи. У роботі використані методи дослідження: проблемно-хронологічний – встановити хронологію наукового вивчення використання аромотерапії; соціологічний – дослідження медико-соціальних якостей поширення патологічних змін у вегетативній нервовій системі; аналітичний – для визначення наукових орієнтирів, застосування доказової медицини в процедурах ароматерапії; метод термінологічного аналізу – для розкриття сутності досліджуваних явищ; метод наукової екстраполяції, що дав змогу визначити можливості створення та застосування ароматерапії як оптимального синтезу теоретичних і практичних знань; методи багатофакторного статистичного аналізу. Результати. Розроблена база даних дозволить легко зорієнтуватися у величезній різноманітності запропонованих видів ефірних олій і дозволить встановити їх відповідність заводу-виробнику. Ароматичні масла, що входять до складу бази, повинні бути перевірені на токсичність і правильність використання. Ця база даних створена з можливістю постійного оновлення та додавання нової інформації у всіх її формах, є початковим етапом створення більш повної версії та може бути затребувана зацікавленими організаціями та окремими особами через Інтернет. Висновки. Запропонована база даних дозволить легко орієнтуватися у величезній різноманітності пропонованих типів ефірних масел і дасть можливість користувачам встановлювати його відповідність із за- водом-виробником.
ASSESSMENT OF MEDICAL ERRORS IN DENTISTRY
(2023) Babkina, O.; Danylchenko, S.; Данильченко, С. І.
The purpose of the work was to analyze the situation with the provision of dental services by medical staff of dental clinics and to analyze medical records to establish/refute the presence of defects in the provision of services. Results. As a result of the analysis of 56 cases of dental services, it was found that surgical dental services (implantation) in most cases are provided in accordance with generally accepted recommendations. In most cases, medical records in dental clinics are properly drawn up, which is of great importance in its study and analysis of the presence/absence of defects during dental manipulations at the time of forensic medical examinations. However, in 10% the medical records of the dental patient were improperly issued, the dates of admission were not specified, the scope of the manipulations performed was not described, the review of the control examination was not scheduled, the necessary instrumental methods of examination were not appointed, the recommendations for cavity care were not provided, etc. Conclusion. The problem of providing services of inadequate quality and improper performance of the professional duties by dental clinics staff, careless and dishonest attitude to their professional duties remains relevant. Medical records data of dental clinics allow experts to analyze the nature, scope, stages and completeness of the provision of dental services, identify/refute the presence of defects in the proper/improper provision of surgical services (implantation) by dental clinics staff, establish/refute a causal relationship between the actions of dental clinics staff and consequences in patients.
ƏZİZ MƏMMƏDKƏRİM OĞLU ƏLİYEV
(2025) Burdina V. R.; Danylchenko S. I.
CASES OF DOMESTIC VIOLENCE - DOCTOR'S ACTIONS AND DOCUMENTING THEM. EXPERIENCE OF UKRAINE
(2024) Babkina, O. P.; Danylchenko, S. I.; Horoshko, V. I.; Данильченко, С. І.
At the legislative level in Ukraine, rights, obligations, benefits for citizens are provided for, normative documents have been developed on the prevention and counteraction of violence, protection and observance of human rights. According to Article 3 of the Constitution of Ukraine, a person, his life and health, honor and dignity, inviolability and security are recognized as the highest social value in Ukraine, human rights and freedoms and their guarantees determine the content and direction of the state's activities. Ensuring human rights and freedoms is the main duty of the state. The purpose article is an analysis and generalization of recommendations regarding the algorithm of actions of medical workers when documenting cases of domestic violence (physical, sexual, psychological, economic) and providing medical and psychological assistance to victims while respecting the rights of patients and ensuring their safety.
COFFEA CRUDA (СИРІ КАВОВІ ЗЕРНА) В ГОМЕОПАТИЧНІЙ МЕДИЦИНІ
(2018) Коньков, А. М.
У статті наводяться короткі дані про наукові засади використання гомеопатичного препарату Coffea cruda, а також пояснюються причини недостатнього впровадження в клінічну практику – гомеопатії як одного з методів нетрадиційної медицини.
COMPLEX REHABILITATION OF ISCHEMIC HEART DISEASE PATIENTS AFTER CORONARY BYPASS OPERATION WITH THE USE OF BIOLOGICALLY ACTIVE ADDITIVES
(2023) Horoshko, V. I.; Yashchyshyn, Z. M.; Danylchenko, S. I.; Morozenko, D. V.; Gliebova, K. V.; Kononenko, N. M.; Yeromenko, R. F.; Данильченко, С. І.
Aim: The purpose of the work was to study the possibility of using Dihydroquercetin in rehabilitation programs for patients with coronary artery disease after Coronary artery bypass grafting (CABG) surgery in order to increase the effectiveness of rehabilitation, which has notable scientific and practical significance. Materials and Methods: The methodological basis of the research is based on systemic, historical, terminological, and informational approaches. Results: The results of the study showed the high clinical effectiveness of Dihydroquercetin in the complex medical rehabilitation of patients with coronary artery disease who underwent the operation. The pill intake did not affect indicators of carbohydrate and lipid metabolism, which indicates its metabolic neutrality. None of the patients had any worsening of the condition, increased frequency of angina attacks, or episodes of painless ischemia. All patients indicated good tolerability of the drug, and improvement in general well-being (reduction or disappearance of shortness of breath, decrease in pain intensity, increase in activity, improvement in sleep). The implementation of the optimized rehabilitation program also contributed to the improvement of the psycho- emotional state of the patients. Conclusions: Сomplex medical rehabilitation of patients with coronary heart disease after Coronary artery bypass grafting surgery according to a program with the inclusion of Dihydroquercetin helps to improve the rheological properties of blood, strengthen the active vasomotor mechanisms of MC regulation, improve indicators of central and peripheral hemodynamics, blood oxygenation, increase in exercise tolerance, improve psycho-emotional the condition, which ultimately ensure an increase in the rehabilitation effect.
COMPREHENSIVE REHABILITATION OF OLDER ADULTS FOLLOWING ACUTE STROKE: EMPHASIS ON THERAPEUTIC EXERCISES AND THE MULTIDISCIPLINARY APPROACH
(2025) Salii A. O.; Danylchenko S. I.; Golovchenko I. V.; Tarasova O. O.; Morozenko D. V.
Background. Stroke remains one of the leading causes of long-term disability worldwide, especially among older adults. Given the increasing incidence of CerebroVascular Accidents (CVAs) in the aging population, there is a growing need for comprehensive, individualized reha- bilitation programs that address the specific physical, cognitive, and emotional needs of elderly patients. Aim. To evaluate the effectiveness of therapeutic exercise as part of a multidisciplinary reha- bilitation approach in elderly patients following an acute stroke. Materials and Methods. The study included 21 patients aged 62 to 79 years who were under- going rehabilitation following an acute CVAs in a district hospital setting. The rehabilitation pro- cess featured a seven-stage individualized program consisting of physical therapy, occupational therapy, speech and language therapy, cognitive training, and psychosocial support. The effec- tiveness of the interventions was evaluated using standardized scales: the Modified Rankin Scale, Barthel Index, Montreal Cognitive Assessment, Visual Analogue Scale, and Borg Rating of Per- ceived Exertion. Results. 76% of the participants (n=16) showed significant improvement in their overall con- dition, including reduced neurological symptoms (aphasia, hemiplegia), enhanced motor skills, better balance, improved emotional well-being, and increased independence in daily activities. The remaining 24% of patients (n=5) also demonstrated positive changes but required additional rehabilitation cycles due to limited recovery potential and complex comorbidities. Conclusions. Individualized therapeutic exercises, integrated within a multidisciplinary reha- bilitation framework, are effective in improving the physical and cognitive outcomes of elderly patients after stroke. Early initiation of rehabilitation, combined with continuous assessment and support from a multidisciplinary team, enhances functional recovery and improves the overall quality of life in this vulnerable population.
CRANIOTOPOGRAPHIC CHARACTERISTICS OF SINUOUS-LIQUOR RELATIONSHIPS IN MATURE PEOPLE
(2023) Bondarenko, S. V.; Dubina, S. O.; Serbin, S. I.; Khapchenkova, D. S.; Fedorova, I. O.; Koptev, M. M.; Danylchenko, S. I.; Бондаренко, С. В.; Дубина, С. О.; Сербін, С. І.; Хапченкова, Д. С.; Федорова, І. О.; Коптев, М. М.; Данильченко, С. І.
The purpose of the study was to determine the craniotopographic (craniometric) indicators of sin- uous-liquor relationships in the horizontal plane in people of the first and second periods of mature age, based on the maximum permissible depth of its intro- duction. Materials and methods. The object of the study was the dura mater of the brain with its sinuses, the ventricles of the brain and the vault of the skull of ma- ture people. The study was performed on 100 corpses of peo- ple of different ages and gender with the manufac- turing of native preparations of the brain with mem- branes and liquor structures. Of the indicated number of morphological objects, 70 preparations of veins and sinuses of the dura mater of the brain and 30 prepara- tions of the cerebrospinal fluid system of the brain of mature people were made. The study used such research methods as: mac- ro- and micropreparation of anatomical objects of the brain; cranio- and morphometry of veins, sinuses of the dura mater of the brain and liquor structures of the brain; manufacturing of corrosive (acrylic) casts – preparations of veins, sinuses of the dura mater of the brain and liquor formations of the brain; injection tech- nique; variational-statistical analysis of morphometric data; computer-graphic analysis. Results and discussion. As a result of the study, it was found that the puncture of the central part of the lateral ventricle is better to be performed at the level of the bregma point, or between this point and the vertex (v). The puncture needle penetrates to a depth of 6.0–7.0 cm through the milling hole, which is displaced by 3.0–4.0 cm from the arrow line at an angle of 70–75°. The obtained data make it possible to determine the most optimal craniometric puncture points of the cerebrospinal fluid system of the brain. To penetrate into the cavity of the anterior horn of the lateral ventri- cle, the metopion point is proposed, which is located at the intersection of the median plane of the head with the line connecting the most convex areas of the frontal humps. The upper puncture of the lateral ventricle is better to be performed by puncturing at the bregma point (the point of connection of the sagittal and cor- onal sutures) 2.0 cm from the midline (sagittal plane); the needle is directed down and backwards and at a depth of 5–6 cm (taking into account that it is enlarged and stretched) it enters the ventricular cavity. The suboccipital puncture or a puncture of the cerebellar-cerebral cistern must be performed be- tween the opisthocranion and lambda points. The puncture needle is inserted to a depth of 6.0–7.5 cm, and the end of the needle is gradually lowered to the base of the skull. Conclusion. The most optimal puncture points of the constituent parts of the cerebrospinal fluid system of the brain – the cavity of the anterior horn and the central part of the lateral ventricle, the cavity of the cerebellar-cerebral cistern – were determined using craniometric analysis. Метою дослідження було визначення у людей першого і другого періодів зрілого віку кра- ніотопографічних (краніометричних) показників пазушно-лікворних взаємовідношень у горизонтальній площині. Матеріал та методи. Об’єктом дослідження були тверда оболона головного мозку з її пазухами, шлуночки головного мозку та склепіння черепа людей зрілого віку. У дослідженні застосовані методи макро- та мікропрепарування анатомічних об’єктів головного мозку; краніо- та морфометрія вен, пазух твердої оболони головного мозку та лікворних структур головного мозку; виготовлення корозійних (акрилових) зліпків – препаратів вен, пазух твердої оболони головного мозку та лікворних утворень головного мозку; ін’єкційна методика; варіаційно-статистичний аналіз морфометричних даних; комп’ютерно-графічний аналіз. Результати дослідження. У результаті дослідження встановлено, що пункцію центральної час- тини бічного шлуночка краще проводити на рівні точки брегма, чи між цією точкою та вертексом (v). Пункційна голка проникає на глибину 6,0–7,0 см через фрезовий отвір, який зміщений на 3,0–4,0 см від стрілової лінії під кутом 70-75°. Верхню пункцію бічного шлуночка краще здійснювати проколом у точці bregma (точка з’єднання стрілового та вінцевого швів) на 2,0 см від серединної лінії (стрілової площини); голку спрямовують донизу та дозаду і на глибині 5–6 см потрапляють у порожнину шлуночка (враховуючи, що вона збільшена та розтягнута). Субокципітальну пункцію або пункцію мозочково-мозкової цистерни необхідно проводити між точками опістокраніон та точкою ламбда. Пункційна голка проводиться на глибину 6,0-7,5 см, причому, з поступовим опусканням кінцевої частини голки до основи черепа. Висновок. Визначені за допомогою краніометричного аналізу найбільш оптимальні точки пункції складових частин лікворної системи головного мозку – порожнини переднього рогу і центральної частини бічного шлуночка, порожнини мозочково-мозкової цистерни.
CRANIOTOPOGRAPHIC FEATURES OF THE TRANSVERSE SINUSES OF THE DURA MATER OF THE BRAIN OF THE CRANIAL VAULT OF MATURE PEOPLE
(2024) Bondarenko, S. V.; Serbin, S. I.; Dubyna, S. O.; Kalyuzhna, V. V.; Bilash, V. P.; Svintsytsʹka, N. L.; Danylchenko, S. I.; Бондаренко, С. В.; Сербін, С. І.; Дубина, С. О.; Калюжна, В. В.; Білаш, В. П.; Свінцицька, Н. Л.; Данильченко, С. І.
The goal of our research is the description of craniotopographic features of the transverse sinuses of the dura mater. The aim and the methods of research. In order to achieve the goal, a set of methods for morphological studies was developed: macro- and micropreparation of anatomical objects of the brain; cranio– the morphometry of veins, sinuses, and the cervian structures of the cephalic brain; preparation of corrosive (acrylic) ulcerative preparations of veins, sinuses of the dura mater and pervoric lesions of the head; injection technique; variational and statistical analysis of morphometric data; computer-graphic analysis. This study was conducted on 70 preparations of veins and sinuses of the dura mater of the brain. Results of the study and their discussion. Considering the above-mentioned facts, we established a craniotopographical projection of the transverse sinuses in relation to generally accepted craniotopographical planes and points. According to the data we have obtained, the venous collectors (transverse sinuses) studied by us have a certain projection analogy on the bones of the cranial vault and the corresponding correlations to the craniometric points, which can be used in medical craniology. In this regard, there is a natural range of individual anatomical variability in the parameters of the dura mater, which are described in people of mature age. The obtained data on the structure, shape, size and position of the venous collectors of the cranial vault (transverse sinuses) can be used in surgical interventions on the cerebrospinal fluid system, including the ventricles and cerebrospinal fluid pathways. Transverse sinuses, located on both sides of the skull in the horizontal plane, are of important practical importance from a neurosurgical point of view. In adults, fully formed right and left transverse sinuses are always noted, which perform an important transport function of carrying venous blood from the drain of the sinuses into the sigmoid sinus and internal jugular veins. The transverse sinuses of the posterolateral surface are adjacent to the inner surface of the parietal and occipital bones, which explains the frequent damage and injury to the collector in various skull injuries. In addition, these collectors must be taken into account during surgical access to various parts of the brain, including the lateral ventricles. Taking into account the above, it is possible to distinguish different areas of the accumulation of veins that flow into the transverse sinuses. The densest location of tributaries, branches and anastomoses is observed in the initial part of the collectors, near the drainage of the sinuses, due to the surface veins of the occipital lobe and the veins of the cerebellar tent. The second place of accumulation of venous vessels is noted in the area of the transition of the transverse sinuses into the sigmoid sinuses, where the superficial temporal and parietal veins are concentrated. Conclusions. The obtained results not only complement the known facts, but also more deeply reveal the prin- ciples of the craniotopographic structure of the transverse sinuses of the dura mater of the cranial vault of people of mature age. On the basis of the actual data obtained, the position is substantiated, according to which a kind of “vascular zone” in the middle part of the transverse sinuses is topographically distinguished, where, in our opinion, it is better to perform surgical interventions in neurosurgical practice. Метою дослідження було встановлення краніотопографічних особливостей поперечних пазух твердої оболони головного мозку склепіння голови (черепа) людей зрілого віку. Матеріал та методи. Дослідження проведено на 70 препаратах вен і пазух твердої оболони головного мозку. За результатами аналізу уточнено топографо-анатомічні положення поперечних пазух дорослої людини; встановлено краніотопографічну проєкцію поперечних пазух стосовно загальноприйнятих краніотопографіних площин і точок; з’ясовано індивідуальну анатомічну мінливість поперечних пазух людини зрілого віку з різними типами будови голови (черепа) за такими досліджуваними ознаками, як: дов- жина, ширина верхньої стінки, ширина задньої стінки, ширина нижньої стінки та висота просвіту; уточнена відома наявність венозних притоків й анастомозів упродовж поперечних пазух. Результати. Встановлено, що вищеперелічені венозні колектори мають певну проєкційну аналогію на кістки склепіння черепа та відповідні співвідношення до краніометричних точок, які можуть бути використані в медичній краніології з урахуванням природного діапазону індивідуальної анатомічної мінливості параметрів твердої оболони головного мозку, котрі описано в людей зрілого віку. Висновки. Встановлено різні ділянки скупчення вен, які впадають у поперечні пазухи. Найбільш густе розташування притоків, гілок і анастомозів можна спостерігати в початковому відділі колекторів, поблизу стоку пазух завдяки поверхневим венам потиличної частки та венам намету мозочка. Друге місце скупчення венозних судин відзначаємо в ділянці переходу поперечних пазух у сигмоподібні, де сконцентровані поверхневі скроневі та тім’яні вени. Тож коли ґрунтуємося на встановленій топографії виділяємо своєрідну «безсудинну зону» в середній частині поперечних пазух, яка є благодатною при виконанні оперативних втручань на венах і синусах твердої мозкової оболони й лікворній системі головного мозку.
DEVELOPMENT OF THE COMPLEX COMPUTER TRAINING PROGRAM IN ORGANIC CHEMISTRY
(2016) Rechytskyi, O.; Reshnova, S.; Varshevskyi, V.
DIAGNOSIS OF BLUNT TRAUMA OF KIDNEY INJURY WITH INFRARED THERMOMETER METHOD
(2020) Babkina, O. P.; Danylchenko, S. I.; Varukha, K. V.; Volobuev, O. E.; Ushko, Ia. A; Бабкина, Е. П.; Данильченко, С. И.; Варуха, Е. В.; Волобуев, А. Е.; Ушко, Я. А.; Данильченко, С. І.
Aim - the study of the prescription of injury on the dynamics of changes in temperature indices of the injured kidney tissues in blunt trauma. The material of the study to date are the tissues of the kidneys of 256 male and female persons, aged 20 to 60 years, who died at a known time of trauma and prescription of death in the were subject to autopsy. To address the question of the age of occurrence of kidney damage, we used a modern method of infrared thermom- etry (using a TH 9100 PMVI-WL Thermo Tracker thermal imager, which is a contactless high-sensitivity infrared camera). In this way, we came to the gown, who, when injured by blunt objects, are willing to take into account the laws of the organs of the black empty. However, in the area of trauma throughout the period after the autopsy of the dead (24 hours of study), observed higher quantitative temperature compared with non-injured kidney tissues, on average, 2-3 ° C (± 0.28). To take into account the fact that the right kidney is protected more than the left kidney and less vulner- able to body compression, it is not accompanied by a shift in the impact of traumatic objects; at 1.5-2 ° C (± 0.14). We believe that determining the limitation period of the onset of mechanical trauma by changes in the infrared thermometry indices carried out in the complex are appropriate and such that provide the full amount of information about the time of causing the trauma. Цель исследования - изучение влияния травмы на дина- мику изменения температурных показателей поврежденных тканей почек при тупой травме. Материалом исследования служили ткани почек, забранные во время вскрытия у 256 мужчин и женщин в возрасте от 20 до 60 лет, умерших от травмы, с известным временем давности наступления травмы и смерти. Для решения вопроса о време- ни повреждения почек применен современный метод инфра- красной термометрии с использованием тепловизора TH 9100 PMVI-WL Thermo Tracker, (NEC Avio infrared Technologies Co. Ltd., Япония), который является бесконтактной высокочув- ствительной инфракрасной камерой. В результате проведенного иссследования установлена характерная динамика изменения температурных показа- телей при травме почек тупым предметом. Однако, в зоне травмы в течение всего периода после вскрытия (24 часа исследования) наблюдались более высокие количественные температурные показатели непосредственно в области трав- мы почки, в среднем, на 2-3°С (±0,28) в сравнении с непо- врежденными тканями почки. Температурные показатели правой почки снижаются медленнее, в среднем, на 1,5-2°С (±0,14) относительно левой, что связано с топографоанато- мическими особенностями расположения почек. Установлено, что при тупой травме в поврежденных и ин- тактных тканях почек наблюдается закономерная динамика уменьшения температурных показателей, что может быть использовано для определения времени наступления трав- мы с помощью метода инфракрасной термометрии.
DIAGNOSTICS OF THE PRESCRIPTION OF DAMAGE TO THE PANCREAS IN EXPLOSIVE TRAUMA AND GUNSHOT WOUNDS DURING A MILITARY CONFLICT
(2022) Babkina, O.; Danylchenko, S.; Данильченко, С. І.
Introduction: Quite often a pancreatic injury is observed in combi- nation with the injury of other organs of the abdominal cavity during explosive trauma and gunshot wounds during a military conflict. Purpose: To study the dynamic changes of histological parameters injured pancreas tissues in various types, depending on the period of injury. Materials and methods: The material for the study included tissues of 52 male and female pancreases, aged from 20 to 54 who died of injury of explosive trauma and gunshot wounds during a military conflict. In the conducted research we used histological and histochemical techniques.
DYNAMICS OF BIOCHEMICAL MARKERS OF THE CONNECTIVE TISSUE METABOLISM IN THE BLOOD OF RATS AFTER INSERTION OF STEEL IMPLANTS WITH DIAMOND-LIKE CARBON COATING INTO THE FEMUR
(2021) Makarov, V.; Morozenko, D.; Gliebova, K.; Danylchenko, S.; Данильченко, С. І.
Objective: It is known that the regeneration of bone tissue after implantation of any structures depends on the coating of their surface. Therefore, the research of the influence of steel implants with diamond-like carbon coating on regeneration of bone tissue in the dynamics after implantation is a topical issue. Material and Methods: The study was conducted on 61 male rats, 5 of them were intact animals. There were also 2 groups of rats with 28 animals in each group (the 1 st group was the control one where implants were without diamond-like carbon coating, the 2 nd group was experimental where the implants were without coating). We determined the content of glycoproteins, chondroitin sulfates, alkaline phosphatase, total calcium, oxyproline and osteocalcin in the blood of rats on the 7th , 14th, 30th and 90th days after implantation. Results and Discussion: Group 2 rats had a faster osteointegration compared with the group 1 rats, which was manifested by the normalization of biochemical markers of bone metabolism (glycoproteins, chondroitinsulfats, oxyproline and osteocalcin) on the 90th day of an experiment. Conclusion: Using steel implants with diamond-like carbon coatings showed that the content of glycoproteins and chondroitin sulfates increased only on the 7th day; oxyproline and osteocalcin increased on the 7th , 14th and 30th days after implantation; on the 90th day the rates of these biochemical markers reached the norm, indicating a high efficiency of osteointegration.
ECOLOGICAL SAFETY PHYTOTESTING OF THE NEW SYNTHETIC PLANT GROWTH – SPIROCARBON DERIVATIVE
(2015) Sidorovich, M.; Kundelchuk, О.; Cot, S.; Rechytskyi, O.; Сидорович, М. М.; Кундельчук, О. П.; Речицький Н. О.